This Our considerable global achievements include a staging system for gynecologic tumours (used in hospitals worldwide); ethical guidelines; harmonisation of scientific terminology; numerous General Assembly resolutions; and various major maternal and newborn health initiatives funded by major global donor bodies. Cancers of the uterine corpus and cervix are the most common gynecologic malignancies worldwide. 8. Stage II endometrial cancer in a 64-year-old woman. Methods From April 1998 to January 2020, women with FIGO stage IA–IB clear cell, serous, and mixed endometrial cancer underwent surgery and adjuvant vaginal cuff brachytherapy. The current American Joint Committee on Cancer (AJCC) (2017) and FIGO (2018) are harmonized so each TNM category has a matching FIGO stage (Box 10.2).Patients’ 5-year disease-free survival is 90% for stage I, 83% for stage II, and 43% for stage III tumors. Objective: To investigate the impact of incorporating pretreatment leukocytosis and/or thrombocytosis in the FIGO staging system on prognostic prediction among women with surgically treated endometrial cancer. For uterine cancer, the staging system developed by the International Federation of Obstetrics and Gynecology (FIGO) is used. Last Revised: July 24, 2020 Signs and Symptoms of Endometrial Cancer€ There are a few symptoms that may point to endometrial cancer. Methods. Merck & Co., Inc., Kenilworth, NJ, USA (known as MSD outside of the US and Canada) is a global healthcare leader working to help the world be well. [3,4] FIGO stages I to IV are further subdivided by the histologic grade (G) of the tumor, for example, stage IB G2. FIGO Staging of Endometrial Carcinoma. (a) Sagittal T2-weighted MR image shows distention of the endometrial cavity by a tumor ( * ) that extends into the cervix (arrow). ... (FIGO) and American Joint Committee on Cancer (AJCC), AJCC Cancer Staging Manual, ed. New York, Springer, 2017. Methods: Retrospective review of clinical data from 900 women with endometrial cancer treated at Osaka University Hospital, Japan, between 2000 and 2016. High-dose rate vaginal cuff brachytherapy was planned to a total dose of 21 gray in three fractions using a multichannel vaginal cylinder. Unusual vaginal bleeding, spotting, or other discharge About 90% of women with endometrial cancer have abnormal vaginal bleeding. FIGO stages for uterine adenocarcinomas. To investigate the impact of incorporating pretreatment leukocytosis and/or thrombocytosis in the FIGO staging system on prognostic prediction among women with surgically treated endometrial cancer. MSD and the MSD Manuals. Clinical staging for endometrial cancer has traditionally been based on histology as well as FIGO staging, said Ritterhouse. The FIGO staging system is the strongest prognostic parameter in patients with endometrial carcinoma. The International Federation of Gynecology and Obstetrics (FIGO) staging system was first established in 1958, when it was recognized that the recurrence rate and patient outcomes were directly related to the degree of tumor spread at the patient’s initial presentation. The FIGO system is the most commonly used staging system for endometrial cancer. Seventy-six patients received chemotherapy. ... 2020; Virtual. Most common gynecologic malignancy in developed countries In the U.S., endometrial cancer is the fourth most prevalent cancer in women (CDC: United States Cancer Statistics [Accessed 24 November 2020]) It also is the sixth most common cause of cancer mortality in women (CDC: United States Cancer Statistics [Accessed 24 November 2020]) Incidence of endometrial cancer is increasing Some are more common as the cancer becomes advanced (grows and spreads). Kandoth C, Schultz N, Cherniack AD, et al. The stage provides a common way of describing the cancer, enabling doctors to work together to plan the best treatments.